As plaque deposits grow, a condition called
atherosclerosis results. This condition causes the arteries to narrow and harden.
Although experts don’t know for sure what starts
atherosclerosis, the process seems to stem from damage to the lining of the arterial wall. This damage, which enables the deposition of plaque, may result from:
Each artery is a muscular tube lined by smooth tissue and has three layers: the intima, the media, and the adventitia.The largest artery is the aorta, which branches into a network of smaller arteries that extend throughout the body. The arteries' smaller branches are called arterioles and capillaries.
- High ''bad'' cholesterol and low ''good'' cholesterol. High levels of ''bad'' cholesterol, or low-density lipoprotein (LDL), are major contributors to arterial plaque formation. But that doesn’t tell the whole story. Everyone also has ''good'' cholesterol, or high-density lipoprotein (HDL), circulating in the blood. HDL is believed to remove some of the bad cholesterol from plaque in clogged arteries and transport it back to the liver, where it is eliminated.
- High blood pressure. Having high blood pressure increases the rate at which arterial plaque builds up. It also hastens the hardening of clogged arteries.
- Cigarette smoke. Cigarette smoke seems to increase the rate of atherosclerosis in the arteries of the heart, legs, and the aorta -- the largest artery in the body.
- Diabetes, or elevated circulating blood sugar, is also a major culprit. Even people who have elevated sugars not yet at the level of diabetes, such as seen in metabolic syndrome, also have increased risk of plaque formation.
- Other risk factors include family history, stress, sedentary lifestyle and obesity. Knowing your family history is critical.
Plaque often starts to develop during the childhood or teenage years. Then clogged arteries develop in middle age or later.
There are a variety of prevention and treatment options for clogged arteries. What your doctor prescribes to reduce arterial plaque and prevent clogged arteries will depend on the severity of your condition and your medical history. Your doctor may prescribe one or more of the following: