I think season 2 of Loki finale ended that... imma nerd out a bit here and go into my interpretation of Loki and how it gave them an out to get rid of Majors and his Kang storyline...
The TVA has been in existence all the while the events in the MCU were happening. One of the things they were doing was hunting down a variant of Loki that was making life unnecessarily difficult for the TVA. They didn't know which one in particular that was the nuisance, and they also felt they couldn't trust any version of Loki they encountered so they entrapped or flat out killed every Loki variant they encountered.
With that said my interpretation of the finale is this:
Loki took the place of a machine that was holding together the threads/fabric of the Multiverse. Before doing this he showed the TRUE enemy of time and the multiverse to be Kang. He then helped to save the key players at the TVA from Kang, so now they're left with a narrative of "Kang bad, Loki good." Now the remnants of the TVA are doing to Kang and his variants what they were doing to Loki and his, which is hunting them down and "pruning" them from existence on each and every branch of the multiversal timeline that Loki is now holding together after sacrificing himself to do so.
They said 2 key things during the ending that to me let me know they (disney) have an out to move away from the Kang storyline with ease and treat it as though it never existed. One, they mentioned Ant Man's encounter with a Kang variant during the finale, saying that there was a deadly encounter with a Kang variant on Earth 616 (that's the earth that's in the MCU) but that the heroes there handled it.
They then said that, to their knowledge, the Kang variants have no idea of the existence of the TVA and what they're doing, so they're being very successful in their mission to eliminate the Kang variants. They said that they're catching them by surprise and just killing them or altering the path of the variant ever so slightly by changing key moments in their life that set them on the path of becoming Kang the Conquerer.
This is shown with them getting rid of Renslayer (Gugu Mbuthu-Raw's character), preventing her from giving a young Victor Timely (a Kang variant) the TVA manual which he used to create the machinery needed for time and multiverse travel.
Essentially this can be written off as just something that has no impact on anyone other than Loki... outside of Ant Man the heroes in the MCU know nothing of this threat, and to his knowledge that threat is dead, AAANNDDDDDD the TVA states that threat was handled so that's that.
They could go off in whatever direction they want to for the next big bad guy terrorizing the MCU, act as if Kang never existed, and we never have to hear from him, Loki or the TVA ever again.
Them bastards, they smart