UPDATE: Donald Trump Takes Office as the 47th US President
- Thread starter DC_Dude
- Start date
Put it on your golf course.
The rural communities... White rural communities are fully capable of being self-sufficient. I want to help Bladk rural communities though.
Who's more at fault, Tlaib for not endorsing Harris or Harris for not taking a stronger stance against Israel? It wouldn't have hurt to have a Palestinian-American to speak at her convention for instance.
Moderna stock soars 177%, Merck jumps 12% after cancer vaccine shows promise in late-stage trial
An experimental personalized cancer vaccine from Merck and Moderna showed positive initial results in its first-ever late-stage trial, the companies announced Wednesday, bringing them one step closer to filing for approval of the treatment option.
The mRNA-based shot in combination with Merck’s immunotherapy Keytruda met key goals in the Phase 3 trial in more than 1,100 patients with higher-risk or advanced melanoma whose detectable cancer had been completely removed through surgery.
Merck shares climbed more than 12% on Wednesday, while Moderna’s stock soared about 177%. The size of those moves reflect the companies’ relative size entering Wednesday: Merck’s market cap was around $333 billion, while Moderna’s sat near $25 billion.
The combination regimen met the main study goal of significantly extending the time patients lived without their melanoma returning, compared with Keytruda alone. The treatment also reduced the risk of the cancer spreading to distant parts of the body. Those results build on positive Phase 2 trial data on the same regimen earlier this year.
“It’s a big moment for medicine, a big moment for patients,” Moderna CEO Stephane Bancel said in an interview on CNBC’s “Squawk Box.”
The Phase 3 study will continue to assess other outcomes, including the overall survival benefit of the regimen. The drugmakers plan to present the data at an upcoming international medical meeting, but it’s unclear when they plan to submit applications for approval in the U.S.
The drugmakers will likely start talking to regulatory agencies about the treatment and its safety “in the next few months,” Dr. Dean Li, president of Merck Research Laboratories, told “Squawk Box.”
The initial data suggests that the combo could serve as a new treatment option for melanoma, which accounts for only about 1% of skin cancers but causes the large majority of deaths among them. Most recurrences of melanoma develop in the first two to three years after initial treatment and removal.
Melanoma patients are “stuck having to deal with the new gravity of that diagnosis and then undergo uncomfortable treatments like surgery, and after that, they’re worried about their cancer coming back,” Dr. Jane Healy, Merck’s head of oncology early development, said in an interview.
She called it “very exciting” that the therapy led to a “clinically meaningful improvement” over Keytruda – the standard of care for melanoma – and was well tolerated by patients. Side effects were similar to other vaccines that people typically get for other diseases, Healy noted.
The results also validate a personalized treatment approach that Merck and Moderna have been developing for decades, she added.
Every tumor has a unique set of mutations, even among patients with the same type of cancer, Healy said. Merck and Moderna’s personalized vaccine is designed to target the specific mutations in each patient’s tumor rather than using a one-size-fits-all approach. The idea is to train the immune system to recognize and kill those unique cancer markers and then pair that response with Keytruda, which helps the body attack the cancer more effectively.
“We think [the results are] very meaningful for patients with this disease and really the potential of what it can mean for other patients for cancer in future trials with this particular new class of therapy,” she said.
In a June note ahead of the results, Leerink Partners analyst Mani Foroohar said the Phase 3 results are a make-or-break event for Moderna’s stock.
Analysts said the company’s valuation already reflected expectations that the personalized cancer vaccine could eventually work across multiple types of cancers – not just melanoma — before Wednesday’s stock move.
Merck and Moderna are studying the vaccine in several trials across other tumors, such as non-small cell lung cancer, bladder cancer and renal cell carcinoma.
Cancer vaccine from Moderna, Merck shows promise in late-stage trial; both stocks soar
The combination regimen significantly extended the time patients lived without their melanoma returning, compared with Keytruda alone.www.cnbc.com
RFK Jr cancels $500m in mRNA vaccine development in the US
Since taking office, the vaccine sceptic has made a number of changes to how vaccines are regulated.
www.bbc.com
Trump....RFK Jr.....and all of MAGA are the idiots holding mankind back through their stupidity
USS Lincoln wasn't resupplied because Hegseth 'hid' that Iran destroyed critical base: Rohde
he following foods have now been recalled:
—Frozen blueberries, possible E. coli contamination
—Iceberg lettuce, possible Cyclospora contamination
—Shell eggs, Salmonella contamination
—Mixed berries, possible E. coli contamination
—Pistachio nut butter, Salmonella contamination
—Green powder supplements, Salmonella contamination
—Jalapeño-containing dips, salsa and guacamole products, Salmonella contamination
—Soup kits, Listeria contamination
—Salad dressings, Salmonella contamination
—Granola, Salmonella contamination
—Dog food, Salmonella contamination
—Jalapeño peppers, Salmonella contamination
—Pizza cheese bread products, Salmonella contamination (July)
—Dried herring fish, Botulism risk (July)
—Requeson cheese, Listeria contamination (July)
—Soft ricotta cheese, Listeria contamination (July)
—Infant formula, Botulism risk (July)
—Multiple cheese varieties, Listeria contamination (July)
—Cottage cheese and ricotta products, Listeria contamination (July)
—Organic moringa capsules and powder, Salmonella contamination (July)
—Smoked whole herring, Botulism risk (June)
—Enoki mushrooms, Listeria contamination (June)
—Parmesan ranch seasoning, Salmonella contamination (June)
—Cheese and garlic croutons, Salmonella contamination (June)
—Tahina, Salmonella contamination (June)
—Specialty beverages, Salmonella contamination (June)
—Multiple green superfood supplements, Salmonella contamination (June)
—Powdered beverage mixes, Salmonella contamination (May)
—Infant formula, Bacillus cereus toxin contamination (May)
—Potato chips, Salmonella contamination (May)
—Pork rinds and seasoning products, Salmonella contamination (May)
—Snack mixes, Salmonella contamination (May)
—Sour cream and onion cheese curds, Salmonella contamination (May)
—Flavored popcorn seasoning, Salmonella contamination (May)
—Coleslaw products, microorganism growth risk (May)
—Pita chips, Salmonella contamination (May)
—Chocolate bars, Salmonella contamination (May)
—White cheddar seasoning, Salmonella contamination (May)
—Kippered herring, Botulism risk (May)
—Peeled garlic, Botulism risk (April)
—Raw milk cheddar cheese, E. coli contamination (April)
—Brain tonic supplements, Botulism risk (April)
—Dried croaker fish, risk of harmful bacteria and toxins (March)
—Salmon products, Listeria contamination (March)
—Cream cheese and tofu spreads, Listeria contamination (March)
—Chicken dog treats, Salmonella contamination (March)
—Yellowfin tuna, Clostridium botulinum contamination (February)
—Organic chia seeds, Salmonella contamination (February)
—Green superfood supplements, Salmonella contamination (February)
—Tamales, potential Listeria contamination (January)
—Shrimp paste, lead contamination risk (January)
—Chocolate bars, Salmonella contamination (January)
—Sea Moss Gel Superfood, Botulism risk (January)
—Cheese products, potential Listeria contamination (January)
But Hunter Biden sold a painting for $50,000
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